2. Signaling Pathways
  3. Cell Cycle/DNA Damage
  4. Nucleoside Antimetabolite/Analog

Nucleoside Antimetabolite/Analog

Nucleoside Antimetabolite/Analog

Related Products

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Nucleoside analogues are molecules that act like nucleosides in DNA synthesis. They include a range of antiviral products used to prevent viral replication in infected cells. Nucleoside analogues can be used against hepatitis B virus, hepatitis C virus, herpes simplex, and HIV. Once they are phosphorylated, they work as antimetabolites by being similar enough to nucleotidesto be incorporated into growing DNA strands. Less selective nucleoside analogues are used as chemotherapy agents to treat cancer, eg gemcitabine and 5-FU. Antimetabolite is a chemical that inhibits the use of a metabolite, which is another chemical that is part of normal metabolism. Such substances are often similar in structure to the metabolite that they interfere with, such as the antifolates that interfere with the use of folic acid. The presence of antimetabolites can have toxic effects on cells, such as halting cell growth and cell division, so these compounds are used as chemotherapy for cancer.

Nucleoside Antimetabolite/Analog Related Products (1901):

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-119530
    Thiamiprine
    Thiamiprine (BW 57-323) is a compound related to azathioprine. Its nucleoside forms are similar to the parent compound in terms of cytotoxicity in vitro (except for the arabinoside). In the rat adjuvant arthritis model in vivo, its riboside and 2'-deoxyriboside are less active than the parent compound. The arabinoside is inactive and nontoxic. It has similar potency to the other parent compounds tested, but has a different safety profile.
    Thiamiprine
  • HY-152805
    9-(2-β-C-Methyl-β-D-ribofuranosyl)purine
    9-(2-β-C-Methyl-β-D-ribofuranosyl)purine is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
    9-(2-β-C-Methyl-β-D-ribofuranosyl)purine
  • HY-152333
    7-n-Butyl-7,8-dihydro-8-oxo-9-(β-D-xylofuranosyl)guanine
    7-n-Butyl-7,8-dihydro-8-oxo-9-(β-D-xylofuranosyl)guanine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
    7-n-Butyl-7,8-dihydro-8-oxo-9-(β-D-xylofuranosyl)guanine
  • HY-154729
    3’-O-Methyl-2’-O-acetyl-5’-O-benzoyluridine
    3’-O-Methyl-2’-O-acetyl-5’-O-benzoyluridine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
    3’-O-Methyl-2’-O-acetyl-5’-O-benzoyluridine
  • HY-154230
    Rev 2’-O-MOE-C(Bz)-5’-amidite
    Rev 2’-O-MOE-C(Bz)-5’-amidite is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
    Rev 2’-O-MOE-C(Bz)-5’-amidite
  • HY-152420
    2-Trifluoromethyl adenosine
    2-Trifluoromethyl adenosine is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
    2-Trifluoromethyl adenosine
  • HY-154397
    2',3',5'-Tri-O-benzoyl-5-azacytidine
    2',3',5'-Tri-O-benzoyl-5-azacytidine is a cytidine analog. Cytidine analogs have a mechanism of inhibiting DNA methyltransferases (such as Zebularine, HY-13420), and have potential anti-metabolic and anti-tumor activities.
    2',3',5'-Tri-O-benzoyl-5-azacytidine
  • HY-W552067
    5-(Hydroxymethyl)-2′,3′-O-(1-methylethylidene)uridine
    5-(Hydroxymethyl)-2′,3′-O-(1-methylethylidene)uridine is a thymidine analog. Analogs of this series have insertional activity towards replicated DNA. They can be used to label cells and track DNA synthesis.
    5-(Hydroxymethyl)-2′,3′-O-(1-methylethylidene)uridine
  • HY-137619A
    Sp-dCTPαS tetrasodium
    Sp-dCTPαS tetrasodium is a sulfur-containing isomer of dGTP (HY-138616). Sp-dCTPαS tetrasodium inhibits SAMHD1 triphosphohydrolase activity with a Ki of 6.3 μM.
    Sp-dCTPαS tetrasodium
  • HY-W400159
    5-Methoxy cytidine
    5-Methoxy cytidine is a cytidine analog. Cytidine analogs have a mechanism of inhibiting DNA methyltransferases (such as Zebularine, HY-13420), and have potential anti-metabolic and anti-tumor activities.
    5-Methoxy cytidine
  • HY-152323
    N1-Methylsulfonyl pseudouridine
    N1-Methylsulfonyl pseudouridine is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
    N1-Methylsulfonyl pseudouridine
  • HY-152974
    1-(2,3,5-Tri-O-benzoyl-2-C-β-methyl-β-D-ribofuranosyl)-5-nitropyridine-2(1H)-one
    1-(2,3,5-Tri-O-benzoyl-2-C-β-methyl-β-D-ribofuranosyl)-5-nitropyridine-2(1H)-one is a nitropyridine nucleoside analogue.
    1-(2,3,5-Tri-O-benzoyl-2-C-β-methyl-β-D-ribofuranosyl)-5-nitropyridine-2(1H)-one
  • HY-154474
    3’,4-Dideoxyuridine
    3’,4-Dideoxyuridine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
    3’,4-Dideoxyuridine
  • HY-W767371
    8-Bromoguanosine-13C,15N2
    8-Bromoguanosine-13C,15N2 is the 13C- and 15N-labeled 8-Bromoguanosine (HY-W019033). 8-Bromoguanosine is a purine nucleoside, a brominated derivative of guanosine. 8-Bromoguanosine can reduce the conformational heterogeneity of RNA to enhance its function.
    8-Bromoguanosine-<sup>13</sup>C,<sup>15</sup>N<sub>2</sub>
  • HY-152432
    1-Amino-7-cyclopropyl methyl-7,8-dihydro-8-oxo-9-(β-D-xylofuranosyl)guanine
    1-Amino-7-cyclopropyl methyl-7,8-dihydro-8-oxo-9-(β-D-xylofuranosyl)guanine is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
    1-Amino-7-cyclopropyl methyl-7,8-dihydro-8-oxo-9-(β-D-xylofuranosyl)guanine
  • HY-152876
    2′-O-Methyl-2-amino-6-chloropurine riboside
    6-Chloro-9-(2-O-methyl-beta-D-ribofuranosyl)-9H-purin-2-amine is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
    2′-O-Methyl-2-amino-6-chloropurine riboside
  • HY-152481
    N1-Methyl-2’-deoxy-2’-fluoroarabinoadenosine
    N1-Methyl-2’-deoxy-2’-fluoroarabinoadenosine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
    N1-Methyl-2’-deoxy-2’-fluoroarabinoadenosine
  • HY-152575
    N6-Methyl-3’-O-(2-methoxyethyl) adenosine
    N6-Methyl-3’-O-(2-methoxyethyl) adenosine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
    N6-Methyl-3’-O-(2-methoxyethyl) adenosine
  • HY-128139
    2'-C-Methylguanosine
    2'-C-Methylguanosine (2'-C-beta-Methylguanosine) is a guanosine analogue. Some guanosine analogs have immunostimulatory activity. In some animal models, they also induce type I interferons, producing antiviral effects. Studies have shown that the functional activity of guanosine analogs is dependent on the activation of Toll-like receptor 7 (TLR7).
    2'-C-Methylguanosine
  • HY-152366
    3’-beta-C-Methyladenosine
    3′-β-C-Methyladenosine is an adenosine analogue. Adenosine analogs mostly act as smooth muscle vasodilators and have also been shown to inhibit cancer progression. The popular products in this series are adenosine phosphate, Acadesine (HY-13417), Clofarabine (HY-A0005), Fludarabine phosphate (HY-B0028) and Vidarabine (HY-B0277).
    3’-beta-C-Methyladenosine